MDM is not a pharmaceutical drug or medication. It is a nutritional supplement; therefore, there is no established dose of MSM. In clinical studies, patients are routinely given doses of 2250mgs. Other experts recommend an initial dose of 2-3 capsules of 1000 mg. a day the first week. The dose may be increased over time. Your optimum effective dosage depends on your weight, size, age, the MSM blood level prior to administration, and the nature and severity of the condition you are treating. MSM does not act immediately. It may take a few days or even a few weeks for a therapeutic level to build up in your system. Your doctor, pharmacist, or qualified holistic health practitioner can help you determine what dose is best for you.